Sorry, folks, it's all downhill from here. Two and a half years of dieting, exercise and glucosamine and nothing much to show for it.
Prevention of osteoarthritic structural damage is the way to go, since there is no cure. Regardless of the initiating cause (trauma, inappropriate loading, autoimmune disease), the inflammation will be funnelled through osteoclast activation, initiating bone remodelling and eventual regeneration of bone and cartilage. However, if the healing/regeneration cannot keep pace with the ongoing damage/degeneration, a net loss of bone and cartilage results in possibly irreversible structural defects we know as periarticular osteopaenia and osteoarthritis.
Bone marrow lesions co-locate exclusively with areas of denuded cartilage, the start of osteoarthritic structural damage
Perhaps anti-resorptives like the Bisphosphonates and Denosumab may prove effective as "DMOADs" & "DMARDs"