Category Archives: The Rheuma Muse

The 9 Muses are daughters of Zeus and Mnemosyne, Greek goddesses personifying the inspiration for the sciences and the arts.
My highly opinionated news-blog draws inspiration from both the science and the art of Rheumatology.

Immunology of Autoimmunity

A Brief History of IL-1 and IL-1 Ra in Rheumatology The history of what, in 1979, was calledinterleukin-1(IL-1), orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP) (1974) and… Interleukin‐9 and T helper type 9 cells in rheumatic diseases Interleukin (IL)‐9 is…
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Immunology of Regeneration

A ‘Mitochondria’ Odyssey Official Full-Text Literature Review: 2016: A ‘Mitochondria’ Odyssey Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
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Immunology & Metabolism

Metabolic Instruction of Immunity Immune cells are exposed to distinct environments and nutrients that influence metabolism that, in turn, instruct their effector functions, differentiation, and gene expression. Cells of the immune system possess particular sets of skills—skills that are vital for host defense and tissue homeostasis but also cause disease if not properly controlled—skills…
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Immunology of Cancer

NLRC5/CITA: A Key Player in Cancer Immune Surveillance Cancer cells need to escape immune surveillance for successful tumor growth. Loss of MHC class I has been described as a major immune evasion strategy in many… Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways Detection of evolutionarily conserved molecules on microbial pathogens by host immune…
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